Medicinal CBD for Breast & Prostate Cancer?

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For those that have heard various stories about CBD oils, here is an abstract of a research article on the use of CBD for breast cancer and other cancers such as prostate.

Review Phyto-, endo- and synthetic cannabinoids: promising chemotherapeutic agents in the treatment of breast and prostatecarcinomas

Pages 1311-1323 | Received 04 Mar 2016, Accepted 12 Sep 2016, Accepted author version posted online: 16 Sep 2016, Published online: 28 Sep 2016

 

Introduction: The term ‘cannabinoids’ designates a family of compounds with activity upon cannabinoid receptors. Cannabinoids are classified in three groups: phytocannabinoids, endocannabinoids, and the synthetic analogues of both groups. They have become a promising tool in the treatment of cancer disease, not only as palliative agents, but also as antitumor drugs, due to their ability to inhibit the proliferation, adhesion, migration, invasion, and angiogenesis of tumour cells. Two of the cancers where they have shown high anticancer activity are breast and prostate tumours. Despite this potential clinical interest, several studies have also reported that cannabinoids can stimulate the proliferation of cancer cells at very low concentrations.

Areas covered: The aim of this review is to evaluate the promising chemotherapeutic utility of phytocannabinoids, endocannabinoids, and synthetic cannabinoids in breast and prostate cancer.

Expert opinion: Cannabinoids, in particular the non-psychoactive CBD, may be promising tools in combination therapy for breast and prostate cancer, due to their direct antitumor effects, their ability to improve the efficacy of conventional antitumor drugs and their usefulness as palliative treatment. Nevertheless, deeper studies to fully establish the mechanisms responsible for their antitumour and pro-tumour properties and their formulation in efficient delivery systems remain to be established.

Additional information

Funding

This paper was funded by the Universidad Complutense de Madrid and the Region of Madrid; A.I Torres-Suarez and A. Fernandez-Carballido are part of the research group ‘Parenteral administration of drugs’ (ref: 910939). A.I. Fraguas-Sánchez has received a University Staff Training fellowship (FPU) from the Ministerio de Educación, Cultura y Deporte (FPU14/06441).

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